abstract：:Viral replication and neutralization of hepatitis C viruses (HCV) have been studied using the infectious molecular clone JFH-1. By passaging JFH-1 in hepatoma cells in the absence or presence of HCV neutralizing antibodies (nAbs), we investigated the molecular mechanisms of cell-culture adaptation and sensitivity to n...

journal_title：Virus research

authors： Song H,Ren F,Li J,Shi S,Yan L,Gao F,Li K,Zhuang H

更新日期：2012-10-01 00:00:00

abstract：:Non-structural protein1β (Nsp1β) of porcine reproductive and respiratory syndrome virus (PRRSV) has been recognized to be involved in suppressing the host innate immune response and mediating viral subgenomic mRNA transcription. In the present study, we have analyzed the interaction of Nsp1β of Chinese highly pathogen...

journal_title：Virus research

authors： Wang L,He Q,Gao Y,Guo X,Ge X,Zhou L,Yang H

更新日期：2012-10-01 00:00:00

abstract：:The hepatitis C virus (HCV) nonstructural protein 3 (NS3) is essential for the processing of the HCV polyprotein, the replication of HCV RNA, and to short circuit innate immunity signaling. NS3 contains an N-terminal domain with protease activity and a C-terminal domain with helicase activity. The two domains communic...

journal_title：Virus research

authors： Vaughan R,Li Y,Fan B,Ranjith-Kumar CT,Kao CC

更新日期：2012-10-01 00:00:00

abstract：:It has recently been reported that the xenotropic murine leukemia virus-related virus (XMRV) derives from a laboratory recombinant. However, sequences with characteristics of the 5' half of XMRV (termed PreXMRV-2) have been identified in several laboratory mouse genomes and cell lines suggesting parts of the XMRV geno...

journal_title：Virus research

authors： Mayer J,Mazzoni CJ,Greenwood AD

更新日期：2012-10-01 00:00:00

abstract：:Equine herpesvirus type 1 and 4 (EHV-1 and EHV-4) are important pathogens of horses worldwide. Infection with EHV-4 usually remains restricted to the upper respiratory tract, whereas infection with EHV-1 can generalize after leukocyte-associated viremia. Here we examined whether differences in the immunomodulatory gly...

journal_title：Virus research

authors： Thormann N,Van de Walle GR,Azab W,Osterrieder N

更新日期：2012-10-01 00:00:00

abstract：:Monocotyledonous plant infecting mastreviruses (family Geminiviridae) have been found in the Old World. The greatest diversity of these viruses has been found in Africa but this may simply reflect the more extensive sampling that has been done there. To provide a better understanding of mastrevirus diversity in Austra...

journal_title：Virus research

authors： Kraberger S,Thomas JE,Geering AD,Dayaram A,Stainton D,Hadfield J,Walters M,Parmenter KS,van Brunschot S,Collings DA,Martin DP,Varsani A

更新日期：2012-10-01 00:00:00

abstract：:Malignant catarrhal fever is a lymphoproliferative disease of cattle and other ungulates caused by infection with gamma-herpesviruses of the genus Macavirus. These viruses do not establish a productive infection but instead replicate in a cell-associated fashion in T lymphocytes, leading to systemic immune dysregulati...

journal_title：Virus research

authors： Russell GC,Benavides J,Grant DM,Todd H,Thomson J,Puri V,Nath M,Haig DM

更新日期：2012-10-01 00:00:00

abstract：:Subgroup J avian leukosis virus (ALV-J) is an oncogenic retrovirus primarily causing myeloid leukosis (ML) in broilers. Although ALV is well under control in a few countries including the USA, poultry industry in many parts of the world continues suffering from serious economic loss due to sporadic or widespread ALV i...

journal_title：Virus research

authors： Li H,Ji J,Xie Q,Shang H,Zhang H,Xin X,Chen F,Sun B,Xue C,Ma J,Bi Y

更新日期：2012-10-01 00:00:00

abstract：:Diagnostic methods allowing for rapid identification of pathogens are crucial for controlling and preventing dissemination after disease outbreaks as well as for use in surveillance programs. For arboviruses, detection of the presence of virus in their arthropod hosts is important for monitoring of viral activity and ...

journal_title：Virus research

authors： Mwaengo D,Lorenzo G,Iglesias J,Warigia M,Sang R,Bishop RP,Brun A

更新日期：2012-10-01 00:00:00

abstract：:Blackberry yellow vein disease (BYVD), a disorder caused by virus complexes, has become a major threat to fresh market blackberry production in the United States. Blackberry yellow vein associated virus (BYVaV) is the most prevalent virus in the BYVD complexes; detected in about 50% of samples exhibiting typical disea...

journal_title：Virus research

authors： Poudel B,Sabanadzovic S,Bujarski J,Tzanetakis IE

更新日期：2012-10-01 00:00:00

abstract：:Cowpox virus (CPXV) host range factor CP77 was identified to be required for virus replication in Chinese hamster ovary (CHO) cells, but the underlying molecular mechanism by which CP77 modulates host range has remained unclear. Therefore, a CPXVΔCP77 deletion mutant was constructed by applying bacterial artificial ch...

journal_title：Virus research

authors： Schuenadel L,Tischer BK,Nitsche A

更新日期：2012-09-01 00:00:00

abstract：:Transplacental viral infections are dependent upon complex interactions between feto-placental and maternal immune responses and the stage of fetal development at which the infection occurs. Bovine viral diarrhea virus (BVDV) has the ability to cross the placenta and infect the fetus. Infection early in gestation with...

journal_title：Virus research

authors： Smirnova NP,Webb BT,Bielefeldt-Ohmann H,Van Campen H,Antoniazzi AQ,Morarie SE,Hansen TR

更新日期：2012-08-01 00:00:00

abstract：:Viruses are most frequently discovered because they cause disease. To expand knowledge of plant-associated viruses beyond these narrow constraints, non-cultivated plants of the Tallgrass Prairie of the United States were systematically surveyed for evidence of viruses. This report discusses putative viruses of the fam...

journal_title：Virus research

authors： Thapa V,Melcher U,Wiley GB,Doust A,Palmer MW,Roewe K,Roe BA,Shen G,Roossinck MJ,Wang YM,Kamath N

更新日期：2012-07-01 00:00:00

abstract：:There are currently no effective drugs to treat serious complications caused by WNV infection. The inhibition of WNV by the pluripotent immunomodulator AS101 [ammonium trichloro(dioxyethylene-0-0')tellurate] was evaluated in vitro and in vivo, and its mechanism was explored. Adding AS101 to Vero cells 1h or 5 min befo...

journal_title：Virus research

authors： Indenbaum V,Bin H,Makarovsky D,Weil M,Shulman LM,Albeck M,Sredni B,Mendelson E

更新日期：2012-06-01 00:00:00

abstract：:Phylogenetic analysis has been extensively used as a tool for the reconstruction of epidemiological relations for research or for forensic purposes. It was our objective to assess the sensitivity of different phylogenetic methods and various phylogenetic programs to reconstruct epidemiological links among HIV-1 infect...

journal_title：Virus research

authors： Beloukas A,Magiorkinis E,Magiorkinis G,Zavitsanou A,Karamitros T,Hatzakis A,Paraskevis D

更新日期：2012-06-01 00:00:00

abstract：:A panel of 6 neutralizing monoclonal antibodies (MAbs) raised against A/Moscow/IIV01/2009 (H1N1) virus isolated during the 2009 pandemic was used for the selection of 26 escape mutants. The mutants were characterized in immune cross-reactions with the panel of MAbs. The sequencing of the mutant HA genes revealed 5 ami...

journal_title：Virus research

authors： Rudneva I,Ignatieva A,Timofeeva T,Shilov A,Kushch A,Masalova O,Klimova R,Bovin N,Mochalova L,Kaverin N

更新日期：2012-06-01 00:00:00

abstract：:We selected Chinese hamster ovary (CHO) cell-adapted strains of human enterovirus 71 (HEV71) belonging to sub-genogroups B5 (HEV71-B5) and C2 (HEV71-C2) by serial passage in CHO cells at a high multiplicity of infection. During the course of CHO cell passage, virus growth improved significantly, with increasing virus ...

journal_title：Virus research

authors： Zaini Z,Phuektes P,McMinn P

更新日期：2012-05-01 00:00:00

abstract：:A double-stranded (ds) RNA, approximately 9.5kb in size; was identified in the MVC86 isolate of Valsa ceratosperma. Complete sequence of the dsRNA revealed a 9543-bp segment (excluding the 3' poly-A tail) that is predicted to encode a single large protein (P330). P330 has 63%, 49%, and 55% amino acid sequence identiti...

journal_title：Virus research

authors： Yaegashi H,Kanematsu S,Ito T

更新日期：2012-05-01 00:00:00

abstract：:This review describes the characterization of porcine circovirus type 2 (PCV2), the field situation of porcine circovirus-associated disease (PCVAD) and the PCV2 vaccine in Korea. PCVAD has been considered the most devastating disease in Korean livestock history since its first outbreak in 1999. Postweaning multisyste...

journal_title：Virus research

authors： Chae C

更新日期：2012-03-01 00:00:00

abstract：:Autophagy is an evolutionarily conserved lysosome-dependent degradation pathway that acts in the maintenance of cellular homeostasis and plays important functions in viral replication and pathogenesis. In this study, we investigated the role of autophagy in the replication of porcine reproductive and respiratory syndr...

journal_title：Virus research

authors： Chen Q,Fang L,Wang D,Wang S,Li P,Li M,Luo R,Chen H,Xiao S

更新日期：2012-02-01 00:00:00

abstract：:The genomic RNA of vitiviruses contains 5 open reading frames (ORF). ORF3 encodes a protein to which the function of a movement protein (MP) was assigned, based on sequence homology with other viral proteins. The aim of the research described in this paper was to gain further insight in distribution profile of the ORF...

journal_title：Virus research

authors： Haviv S,Moskovitz Y,Mawassi M

更新日期：2012-01-01 00:00:00

abstract：:Hamster polyomavirus (HaPyV) major capsid protein VP1 based chimeric virus-like particles (VLPs) carrying model GP33 CTL epitope derived from Lymphocytic choriomeningitis virus (LCMV) were generated in yeast and examined for their capability to induce CTL response in mice. Chimeric VP1-GP33 VLPs were effectively proce...

journal_title：Virus research

authors： Mazeike E,Gedvilaite A,Blohm U

更新日期：2012-01-01 00:00:00

abstract：:Expression of the rotavirus enterotoxin (NSP4) in transfected monkey kidney cells was found to result in a dramatic re-modeling of the microtubule (MT) network. This important centrosome organized cytoskeletal element was dissolved by expression of NSP4 and re-formed in a ring array at the periphery of the cell, simil...

journal_title：Virus research

authors： Yang W,McCrae MA

更新日期：2012-01-01 00:00:00

abstract：:The rabies viruses that circulate in Arctic countries and in much of northern and central Asia are phylogenetically closely related and collectively referred to as the Arctic/Arctic-like (AL) lineage. The emergence and spread of this lineage is of significant interest given that rabies remains a serious zoonotic disea...

journal_title：Virus research

authors： Nadin-Davis SA,Sheen M,Wandeler AI

更新日期：2012-01-01 00:00:00

abstract：:Tobacco mosaic virus (TMV) is a positive-sense plant RNA virus which has a wide host range and a worldwide distribution. Other than a troublesome pathogen, TMV is regarded as a model system pioneering biologic research for a century. The tomato strain of TMV has been recognized to be a distinct tobamovirus as the toma...

journal_title：Virus research

authors： He M,He CQ,Ding NZ

更新日期：2012-01-01 00:00:00

abstract：:West Nile virus (WNV) and Japanese encephalitis virus (JEV), the members of JEV serocomplex group are pathogens of global health concern. The co-circulation of these viruses poses challenges in effective diagnostics due to antigenic similarity between the E-protein of these viruses. The present study aimed to design c...

journal_title：Virus research

authors： Gangwar RS,Shil P,Sapkal GN,Khan SA,Gore MM

更新日期：2012-01-01 00:00:00

abstract：:While a large number of negative-strand (-)RNA viruses infect animals and humans, a relative small number have plants as their primary host. Some of these have been classified within families together with animal/human infecting viruses due to similarities in particle morphology and genome organization, while others h...

journal_title：Virus research

authors： Kormelink R,Garcia ML,Goodin M,Sasaya T,Haenni AL

更新日期：2011-12-01 00:00:00

abstract：:Mixed viral infections can induce different changes in symptom development, genome accumulation and tissue tropism. These issues were investigated for two phloem-limited begomoviruses, Abutilon mosaic virus (AbMV) and Tomato yellow leaf curl Sardinia virus (TYLCSV) in Nicotiana benthamiana plants doubly infected by ei...

journal_title：Virus research

authors： Sardo L,Wege C,Kober S,Kocher C,Accotto GP,Noris E

更新日期：2011-11-01 00:00:00

abstract：:A prospective, cross-sectional study was conducted to investigate the correlation between the integration of high-risk human papillomavirus and disease severity of cervical lesions. 720 liquid-based cytology specimens including 422 normal cytology, 78 low-grade squamous intraepithelial lesions, 172 high-grade squamous...

journal_title：Virus research

authors： Ho CM,Lee BH,Chang SF,Chien TY,Huang SH,Yan CC,Cheng WF

更新日期：2011-11-01 00:00:00

abstract：:Hepatitis E is acute hepatitis caused by infection of hepatitis E virus (HEV) via a fecal-to-oral or zoonotic route. HEV is a small, non-enveloped virus containing positive strand RNA as a genome. Recently, the three-dimensional structures of the HEV-like particles and spike domain protruded from the surface of the pa...

journal_title：Virus research

authors： Mori Y,Matsuura Y

更新日期：2011-10-01 00:00:00

abstract：:We previously established inducible-hepatitis C virus (HCV) transgenic mice, which expressed the HCV gene (nucleotides 294-3435) encoding the core, E1, E2, and NS2 proteins. The expression of these proteins is regulated by the Cre/loxP system and an adenovirus vector (AdV) that expresses Cre DNA recombinase (Cre) cont...

journal_title：Virus research

authors： Chiyo T,Sekiguchi S,Hayashi M,Tobita Y,Kanegae Y,Saito I,Kohara M

更新日期：2011-09-01 00:00:00

abstract：:Viruses and virus-like particles (VLPs) of insect parasitoids modify host-parasite interactions. The Drosophila wasp, Leptopilina heterotoma, produce 300 nm spiked VLPs that bind to the host's blood cells via surface projections. L. heterotoma is a generalist wasp that attacks over a dozen Drosophila species. Oviposit...

journal_title：Virus research

authors： Gueguen G,Rajwani R,Paddibhatla I,Morales J,Govind S

更新日期：2011-09-01 00:00:00

abstract：:Confocal microscopy revealed that Rice dwarf virus (RDV) initially accumulated in epithelial cells of the filter chamber of leafhopper vector Nephotettix cincticeps 2 days after acquisition access feeding on diseased plants. Subsequently, RDV accumulation progressed to the anterior midgut, and then spread to the nervo...

journal_title：Virus research

authors： Chen H,Chen Q,Omura T,Uehara-Ichiki T,Wei T

更新日期：2011-09-01 00:00:00

abstract：:The attenuated equine infectious anemia virus (EIAV) vaccine was the first attenuated lentivirus vaccine to be used in a large-scale application and has been used to successfully control the spread of equine infectious anemia (EIA) in China. To better understand the potential role of cytokines in the pathogenesis of E...

journal_title：Virus research

authors： Lin YZ,Cao XZ,Li L,Li L,Jiang CG,Wang XF,Ma J,Zhou JH

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND AND AIM:The mechanisms of hepatocarcinogenesis induced by hepatitis C virus remain unclear. Our aim was to investigate the effect of the HCV core protein on the promoter methylation status of selected genes potentially involved in the hepatocellular carcinoma (HCC). MATERIALS AND METHODS:We evaluated the pr...

journal_title：Virus research

authors： Ripoli M,Barbano R,Balsamo T,Piccoli C,Brunetti V,Coco M,Mazzoccoli G,Vinciguerra M,Pazienza V

更新日期：2011-09-01 00:00:00

abstract：:Rat theilovirus (RTV) is a cardiovirus related to Theiler's murine encephalomyelitis virus. While RTV is a prevalent viral pathogen of rats used in biomedical research, the pathogenesis and characterization of RTV infections is not well understood. In the studies reported herein, we used immunohistochemistry to identi...

journal_title：Virus research

authors： Drake MT,Besch-Williford C,Myles MH,Davis JW,Livingston RS

更新日期：2011-09-01 00:00:00

abstract：:Between 2006 and 2009, 10 field experiments were done at Kununurra, Carnarvon or Medina in Western Australia (WA) which have tropical, sub-tropical and Mediterranean climates, respectively. These experiments investigated the effectiveness of cultural control measures in limiting ZYMV spread in pumpkin, and single-gene...

journal_title：Virus research

authors： Coutts BA,Kehoe MA,Jones RA

更新日期：2011-08-01 00:00:00

abstract：:In order to understand the factors influencing pathogenicity of a virus, two neutralization escape (NE) variants were selected from wild type lineage 1 West Nile virus (WNV) 68856 strain pathogenic by intra-peritoneal (i.p.) route using monoclonal antibodies (MAbs) against envelope (E) protein. Both NE IF1A7 1.1 and N...

journal_title：Virus research

authors： Sapkal GN,Harini S,Ayachit VM,Fulmali PV,Mahamuni SA,Bondre VP,Gore MM

更新日期：2011-06-01 00:00:00

abstract：:Picobirnaviruses possess a bisegmented double-stranded RNA genome. While the segment 2 encodes the RNA-dependent RNA polymerase, the segment 1 displays two open reading frames (ORFs). ORF2 was recently shown to code the capsid precursor and ORF1 product has not been characterized. In this study, we show that the three...

journal_title：Virus research

authors： Da Costa B,Duquerroy S,Tarus B,Delmas B

更新日期：2011-06-01 00:00:00

abstract：:The development of cell-mediated immunity has been known extremely important in clearing porcine reproductive and respiratory syndrome virus (PRRSV) in infected pigs. However, the PRRS immunology regarding the interaction of T-cells and PRRSV proteins is poorly understood. To identify the T-cell immunodominant epitope...

journal_title：Virus research

authors： Wang YX,Zhou YJ,Li GX,Zhang SR,Jiang YF,Xu AT,Yu H,Wang MM,Yan LP,Tong GZ

更新日期：2011-06-01 00:00:00